the US Food and Drug Administration (FDA) limits the quinine content in tonic water to 83 ppm[3] (83 mg per litre if calculated by mass), while the daily therapeutic dose of quinine is in the range of 167–333 mg.[4] Still, it is often recommended as a relief for leg cramps, but medical research suggests some care is needed in monitoring doses.[5] Because of quinine's risks, the FDA has declared nonprescription sources, such as tonic water, should not be used to prevent or treat leg cramps