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Cell Biology
Developmental mitochondrial complex I activity determines lifespan👇 📎Many human diseases are associated with aberrant mitochondrial function. 📎The authors show that developmental but not adulthood complex I (CI) depletion reduces lifespan, increases stress sensitivity and alters metabolic homeostasis despite comparable reduction in CI activity but, depletion of CI in adulthood only is not sufficient to reduce lifespan in Drosophila. 📎They also demonstrate that CI dysfunction in early…
