The Lie Tree by Frances Hardinge. This piece of historical fiction provides an excellent sense of the time of Darwin, along with a very strong sense of the level of science being practiced (with the exception of the titular tree).
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Gabriella Mondini is a rarity in century Venice: a woman who practices medicine. Her father, a renowned physician, has provided her entree to this all male profession, and inspired in her a shared mission to understand the secrets of the human body.