Pepperoni Chips- Line a Microwave-Safe Plate with several sheets of papertowel. Place the pepperoni slices in a single layer. 2 Microwave for 30 - 60 seconds (depending on the wattage of your microwave). The pepperoni slices should be nice and crispy and most of the grease absorbed on the papertowels. 3 If any in the center are not crispy looking and still feel soft, microwave more in 15 second increments.