Omega-3/Aging telomere papers

Collection by Norwegian PURE-3 • Last updated 11 weeks ago

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Norwegian PURE-3
Exploiting the telomere machinery to put the brakes on inflamm-aging In Vivo, Environmental Factors, Omega, Science, Science Comics

Exploiting the telomere machinery to put the brakes on inflamm-aging

Mice with hyper-long telomeres show less metabolic aging and longer lifespans Brown Adipose Tissue, Mitochondrial Dna, Low Cholesterol, Stem Cells, Mice, Metabolism, Omega, Cancer

Mice with hyper-long telomeres show less metabolic aging and longer lifespans

Short telomeres trigger age-related pathologies and shorter lifespans in mice and humans. In the past, we generated mouse embryonic (ES) cells with longer telomeres than normal (hyper-long telomeres) in the absence of genetic manipulations, which contributed to all mouse tissues. To address whether hyper-long telomeres have deleterious effects, we generated mice in which 100% of their cells are derived from hyper-long telomere ES cells. We observe that these mice have longer telomeres and…

  Omega

Telomeres Increasingly Develop Aberrant Structures in Aging Humans

Abstract. Telomeres progressively shorten with age, and it has been proposed that critically short and dysfunctional telomeres contribute to aging and aging-as

  Cerebrospinal Fluid, Activities Of Daily Living, Seong, Alzheimers, Dementia, Omega, Clinic, Conversation

Aging | Telomere shortening reflecting physical aging is associated with cognitive decline and dementia conversion in mild cognitive impairment due to Alzheimer’s disease - Full Text

Full Text - We investigated whether telomere length (TL) reflecting physical rather than chronological aging is associated with disease progression in the different cognitive stages of Alzheimer’s disease (AD). Study participants included 89 subjects with amyloid pathology (A+), determined through amyloid PET or cerebrospinal fluid analysis, including 26 cognitively unimpaired (CU A+) individuals, 28 subjects with mild cognitive impairment (MCI A+), and 35 subjects with AD dementia (ADD A+)…

  Communication Articles, Environmental Factors, Oxidative Stress, Transcription, Aging Process, Genetics, Omega

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

Chronic inflammation is associated with normal and pathological ageing. Here we show that chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of the transcription factor NF-κB induces premature ageing in mice. We also show that these mice have reduced regeneration in liver and gut. nfkb1−/− fibroblasts exhibit aggravated cell senescence because of an enhanced autocrine and paracrine feedback through NF-κB, COX-2 and ROS, which stabilizes DNA damage…

Schizophrenia is associated with shortening of the lifespan mainly due to cardiovascular events, cancer and chronic obstructive pulmonary disease. Schizophrenia, Psychiatry, Trials, Omega, Clinic, Cancer, Science, Science Comics, Psych

Telomerase level increase is related to n-3 polyunsaturated fatty acid efficacy in first episode schizophrenia: Secondary outcome analysis of the OFFER randomized clinical trial

Schizophrenia is associated with shortening of the lifespan mainly due to cardiovascular events, cancer and chronic obstructive pulmonary disease. Bot…

Polyunsaturated fatty acids ameliorate aging via redox-telomere-antioncogene axis Fish Oil, Omega, Anti Aging

Polyunsaturated fatty acids ameliorate aging via redox-telomere-antioncogene axis

Polyunsaturated fatty acids (PUFA), a group of nourishing and health-promoting nutrients, ameliorate age-related chronic diseases. However, how PUFA especially n-3 PUFA exert anti-aging functions remains poorly understood. Here we link fish oil, docosahexaenoic ...

The red blood cell proportion of arachidonic acid relates to shorter leukocyte telomeres in Mediterranean elders: A secondary analysis of a randomized controlled trial Randomized Controlled Trial, Red Blood Cells, Trials, Omega, Clinic

The red blood cell proportion of arachidonic acid relates to shorter leukocyte telomeres in Mediterranean elders: A secondary analysis of a randomized controlled trial

Shortening of leukocyte telomere length (LTL) is a biomarker of aging. Epidemiologic studies of LTL in relation to dietary fatty acids have reported c…

Fatty Acids, Oxidative Stress, and Leukocyte Telomere Length: A Randomized Controlled Trial Randomized Controlled Trial, Oxidative Stress, Trials, Omega

Omega-3 Fatty Acids, Oxidative Stress, and Leukocyte Telomere Length: A Randomized Controlled Trial

Shorter telomeres have been associated with poor health behaviors, age-related diseases, and early mortality. Telomere length is regulated by the enzyme telomerase, and is linked to exposure to proinflammatory cytokines and oxidative stress. In our recent ...

Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease Chronic Kidney Disease, Oxidative Stress, Cardiovascular Disease, Omega

n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease

DNA telomere shortening associates with the age-related increase cardiovascular disease (CVD) risk. Reducing oxidative stress, could modify telomere erosion during cell replication, and CVD risk in patients with chronic kidney disease (CKD). The effect ...

Association of Marine Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease Omega 3

Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease

ContextIncreased dietary intake of marine omega-3 fatty acids is associated with prolonged survival in patients with coronary heart disease. However, the mechan

Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats White Blood Cell Count, White Blood Cells, Weight Gain, Body Weight, Scientific Reports, Gene Expression, Oxidative Stress, Fish Oil, Cholesterol

Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats

The impact of dietary soybean oil, lard and fish oil on physiological responses in middle age is little studied. In this study, we investigated the changes of oxidative stress, inflammatory cytokines, telomere length, and age-related gene expression in the liver of middle-aged rats in response to the above three fat diets. Male Sprague Dawley rats (12 months old) were fed AIN-93M diets for 3 months, in which soybean oil was equivalently replaced by lard or fish oil. As compared to the lard…

Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with fatty acid supplementation: A randomized controlled pilot study Oxidative Stress, Omega, Study, Science, Studio, Science Comics, Learning, Research, Studying

Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: A randomized controlled pilot study

Excessive shortening of the telomeric ends of chromosomes is a marker of accelerated aging. Oxidative stress and nutritional deficiency may influence …

Chronic stress is associated with the accelerated aging of the immune system and represents a potent risk factor for the development and progression o… Chronic Stress, Immune System, Omega, Science, Science Comics

Stress and immunosenescence: The role of telomerase

Chronic stress is associated with the accelerated aging of the immune system and represents a potent risk factor for the development and progression o…

Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease Growth Factor, Omega, Novels, Science, Science Comics, Fiction, Romance Novels, Romans

Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease

Telomere length (TL), growth differentiate factor (GDF)11, insulin growth factor (IGF)1, sirtuin (SIRT)1 and inflammatory processes have been related …

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