Puppies’ bodies can shake for many reasons, from excitement to pain, nausea, or fever. While the reason could be temporary and harmless, if you’ve brought a new puppy home and see your puppy shaking or even having regular shaking episodes, it may be a cause for concern. Specifically, the shaking can be a result of shaking puppy syndrome, which can cause tremors, poor muscle control, and even seizures in young dogs.